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KMID : 0383820090660020110
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Tuberculosis and Respiratory Diseases
2009 Volume.66 No. 2 p.110 ~ p.115
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Comparison of Forcep-biopsy and Cryo-biopsy by a Flexible Bronchoscopy
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Kim Jae-Hyun
Choi Jung-Min
Song Sung-Eun
Lee Eun-Mi
Lee Song-Ju
Oak Chul-Ho
Jang Tae-Won
Jung Maan-Hong
Chang Hee-Kyung
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Abstract
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Background: A forceps-biopsy is performed to acquire tissue from patients with an endobronchial carcinoma using a flexible bronchoscope. Recently, a cryo-biopsy has also been used to acquire tissue samples. Cryo-biopsy is the diagnostic application of extreme cold for the local destruction of abnormal living tissue. This technique is safe, with no radiation danger, no risk of electrical accidents, and a little risk of bleeding. This study compared a forceps-biopsy with a cryo-biopsy using a flexible bronchoscope, and examined the chemosensitivity and level of VEGF (vascular endothelial growth factor) in the specimens obtained from the cryo-biopsy.
Methods: We present a prospective study of 30 consecutive patients who underwent a forceps-biopsy between January 2007 and October 2007 with a mean age of 62.1 years and a male:female ratio of 5 : 1. A flexible bronchoscope was inserted to the area of the abnormal lesions, and a cryo-probe was then applied through the working channel of the flexible bronchoscope. A temperature of approximately -80 was delivered to the tumor site for 8 seconds. The cryo-biopsy was performed after destroying the tumor mass.
Results: The mean size of the tissue from the forceps-biopsy and cryo-biopsy were 2.0±1.2 mm and 6.0±3.0 mm. A chemosensitivity test was performed on 5 specimens obtained using cryo-biopsy and the level of VEGF was examined in 2 specimens obtained from a cryo-biopsy. There were no side effects in either group.
Conclusion: Cryo-biopsy using a flexible bronchoscope is a safe and effective technique for acquiring tissue samples.
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KEYWORD
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Forcep-biopsy, Cryo-biopsy, Endobronchial carcinoma
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